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When Aesthetics and Neuroscience Meet
At the intersection of aesthetics, neuroscience, and psychiatry, aesthetic medicine goes beyond appearance to influence emotional processing, stress-related conditions, self-image, and overall well-being through a holistic, patient-centered approach that treats the whole individual.
By: Dr. Jimena Ortiz Perpuli
January 28, 2026

Aesthetic medicine is rarely just about appearance. In many cases, it becomes an entry point to understanding how emotions, stress, and mental health are reflected on the face and body. As a physician specialized in facial and body aesthetics and a professor of Neurosciences II (Psychiatry), I work at the intersection of these two disciplines every day. 

One of the most compelling examples is the use of botulinum toxin in facial muscles. Beyond smoothing lines, modulating facial expression can influence emotional processing. Patients who reduce constant frowning or tense expressions often describe feeling calmer and emotionally lighter. While botulinum toxin is not a treatment for depression, this phenomenon highlights the feedback loop between facial expression, neural pathways, and mood. 

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Another common clinical scenario involves bruxism, a condition strongly associated with stress and anxiety. When neuromodulation is used to reduce muscle hyperactivity, patients frequently experience functional improvements such as decreased pain, less muscle tension, and better sleep quality, changes that can significantly improve daily performance and overall well-being. 

Separate from functional conditions, aesthetic treatments can also have a meaningful impact on self-image and self-esteem. When patients feel more aligned with their appearance, they often gain confidence that positively influences social interaction, emotional stability, and quality of life. This psychological dimension is especially important to recognize and approach with responsibility and ethical awareness. 

Teaching psychiatry allows me to emphasize to students that aesthetic medicine should never be disconnected from mental health. Patients are not only seeking physical changes; they are often seeking balance, comfort, and a better relationship with themselves. 

For me, neuroscience and aesthetics are not separate fields, but complementary ways of understanding and caring for the whole patient. 

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